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List of promising therapeutics to treat long COVID

List of promising therapeutics to treat long COVID which is compiled by the Foundation for the National Institutes of Health.

DRUG SUBMISSIONS
ANTIVIRAL
Abacivir Acyclovir Atovaquone (alone or in combination with Afenoquine/ Daptomycin/ Amoxicillin/ Clavulanate/ Rifaximin/ Ceftriaxone/ Cefuroxime/ Dapagliflozin/ Venetoclax/ Valganciclovir/ Metformin/ Methylene Blue/ Methylsulfonylmethane/ Vitamin D3) Azvudine (alone or in combination with GB-0669) Casirivimab Combination SARS-CoV-2 antivirals (direct-acting antivirals) COVID monoclonal antibodies COVID vaccines Dapsone Daptomycin EDP-235 Ensitrelvir Evusheld GB-0669 Ibuzatrelvir	IMC-2 (valacyclovir-celecoxib fixed dose combination) Imdevimab Imunovir Keptide Maraviroc (alone or in combination with pravastatin) Moxifloxacin Obeldesivir Paxlovid PB 301 REGEN-COV Remdesivir Rimteravimab Rintatolimod Ritonavir Suramin Tenofovir (alone or in combination with Sandimmune / Sirolimus/ Abacavir) XVR013m
IMMUNOMODULATORS
Alpha-1-Antitrypsin Augmentation Therapy Anti-CGRP therapy Antihistamines (alone or in combination with naltrexone and fexofenadine) Apheresis Baricitinib BC007 Belimumab Benralizumab Budesonide Bisoprolol Checkpoint inhibitors (alone or in combination with JAK inhibitors) Cimetidine (alone or in combination with Sodium Phenylbutyrate/Propranolol/Acyclovir/Ascor) Colchicine Copaxone Corticosteroids CXCR4 inhibitors Cyclosporine Daratumumab (alone or in combination with Belimumab/Rituximab/Inebilizumab/Tafasitamab) Dexamethasone Diclofenac Sodium Topical Gel 1% Dupilumab Efgartigimod (or nipocalimab, rosanolixizumab) Famotidine (alone or in combination with Hydroxyzine/Cetirizine/Loratadine/ fexofenadine) Fibroquel Fibrinogen immunotherapy Filgotinib H1/H2 blockers Heparin-induced Extracorporeal Low-density Lipoprotein Precipitation Hydrocortisone IL-6 Inhibitors Imatinib Immunomodulators Intrathecal stem cell therapy Inspiritol	INUSpheresis IVIG (alone or in combination with Xolair or naltrexone) JAK/STAT inhibitors (alone or in combination with checkpoint inhibitors) Ketotifen Leronlimab MCAS medications Meloxicam Methotrexate low dose Montelukast Mrgprx2 antagonists N-acetylcysteine Nasal sprays NK Cell therapy DVX201 Pegylated interferon lambda Pentoxyifilline Plasmapheresis POLB001 Prednisone Rapamycin (low dose) Rituximab Rozanolixizumab RSLV-132 SCIG Selnoflast Sertraline Sulodexide SYX-1042 Tafasitamab Teclistamab Tempol Thymosin Alpha 1 Thymalfasin Tocilizumab Trelegy Triple anticoagulant therapy Vilobelimab Xycam Xyzal
NEUROLOGICAL AGENTS
Acetaminophen Amantadine Aripiprazole (alone or in combination with Naltrexone) ASHA-091 Carbidopa and levodopa combination Cerebrolysin and SS31 combination peptide injections Clonidine CT38 Dexmethylphenidate Dextromethorphan Dextro-naltrexone Dual stellate ganglion nerve block Gamma-aminobutyric acid (GABA) Guanfacine (alone or in combination with N-acetylcysteine) Idebenone Ondansetron Ketamine Lamotrigine MDC002 Methylphenidate	Microglial inhibitors (including but not limited to Ibudilast) Modafinil Morphine Naltrexone (low dose, alone or in combination with Allergra/Aripiprazole/Fexofenadine/Fluvoxamine) Nicotine patches (alone or in combination with Ivabradine/LDN/MCAS tx/aspirin) Nimodipine Omalizumab Pregabalin SBT-272 Sodium Oxybate Stimulant therapy Theophylline Trazodone Venlafaxine Xanax/Alprazolam XVR011 Zatomilast Zuranolone
HOST-DIRECTED
Albuterol sulfate Amlodipine besylate Anti-purinergic agents Aspirin Atorvastatin (alone or in combination with Maraviroc) Bisoprolol Dabigatran Dapagliflozin Fluticasone propionate/nasal spray GLP-1 receptor agonists Hormone replacement therapy Hydroxychloroquine Hydroxyurea Ibuprofen Imodium Insulin glargine Ipratropium bromide/albuterol	Ivabradine (alone or in combination with low dose naltrexone/MCAS tx/aspirin/nicotine patches) Matrix metallopeptidase 2 (MMP2) Metformin Methylene blue Midodrine Pioglitazone Promethazine/Codeine Propranolol Rabeprazole Rixoroxaban Rosuvastatin Salubrinal Semaglutide Suberoylanilide hydroxamic acid (SAHA) inhibitors Sunitinib Trimetazidin Vericiguat Zonulin antagonists (larazotide)

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