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PEA-NBOH/NBOMe

Salicylic acid --Decarboxylation--> Phenol --Reimer-Tiemman--> Salicylaldehyde (methylation if you want the N 2 MeO benzyl)+Phenetylamine--Reductive amination--> PEA-NBOH (N-(2-hydroxy benzyl)phenethylamine

Posible active Psychedelic 5-HT2A agonist? OPIOD?

Its missing the magic 2,5 dimethoxy 4-X substitution pattern that most pychedelic Phenethylamines have. I believe it is going to be active, whathever it does, the N-benzyl part probably protects the nitrogen from metabolism to some degree, but it starts to look very different from the other phenys. the only interesting part is the accesibility of the precursors, except with the reducing agents in the reductive amination step, some borohydrides are going to become watched chemicals soon (or are they now?) but there are still options like sodium Hypophospithe.



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